Sample Size Calculations in Clinical Research PDF
By:Shein-Chung Chow,Hansheng Wang,Jun Shao
Published on 2003-03-04 by CRC Press
Sample size calculation plays an important role in clinical research. It is not uncommon, however, to observe discrepancies among study objectives (or hypotheses), study design, statistical analysis (or test statistic), and sample size calculation. Focusing on sample size calculation for studies conducted during the various phases of clinical research and development, Sample Size Calculation in Clinical Research explores the causes of discrepancies and how to avoid them. This volume provides formulas and procedures for determination of sample size required not only for testing equality, but also for testing non-inferiority/superiority, and equivalence (similarity) based on both untransformed (raw) data and log-transformed data under a parallel-group design or a crossover design with equal or unequal ratio of treatment allocations. It contains a comprehensive and unified presentation of statistical procedures for sample size calculation that are commonly employed at various phases of clinical development. Each chapter includes, whenever possible, real examples of clinical studies from therapeutic areas such as cardiovascular, central nervous system, anti-infective, oncology, and women's health to demonstrate the clinical and statistical concepts, interpretations, and their relationships and interactions. The book highlights statistical procedures for sample size calculation and justification that are commonly employed in clinical research and development. It provides clear, illustrated explanations of how the derived formulas and/or statistical procedures can be used.
This Book was ranked at 5 by Google Books for keyword Research.
Book ID of Sample Size Calculations in Clinical Research's Books is CBh0D6bMFTIC, Book which was written byShein-Chung Chow,Hansheng Wang,Jun Shaohave ETAG "/oTo2mp5A5Y"
Book which was published by CRC Press since 2003-03-04 have ISBNs, ISBN 13 Code is 9780203911341 and ISBN 10 Code is 0203911342
Reading Mode in Text Status is false and Reading Mode in Image Status is true
Book which have "358 Pages" is Printed at BOOK under CategoryMathematics
Book was written in en
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